Abstract:OBJECTIVE To explore the pharmacological effects of carbapenem antibiotics and analysis of its clinical application. METHODS 100 patients with pulmonary infection admitted from January 2017 to January 2018 were selected as research objects, 50 patients treated with cefoperazone and sulbactam were taken as control group, and 50 patients treated with cefoperazone and sulbac⁃ tam combined with imipenem cilastatin sodium were taken as research group. The clinical related indexes, pulmonary function and ad⁃ verse reactions of the two groups were compared. RESULTS After treatment, the bacteriological examination recovery time and other clinical related indexes in the study group were better than the control group（P＜0.05）. Each index level of lung function in the two groups after treatment was better than that before treatment, and the optimization range was larger with RV/TLC of (0.41±0.02)% and FEV1/FVC of (0.67±0.12)% in the study group（P＜0.05）. The total incidence of adverse reactions in the study group was 2.00%, sig⁃ nificantly lower than the control group（P＜0.05）. CONCLUSION The effect of cefoperazone sulbactam and carbapenem drugs on pa⁃ tients with pulmonary infection was better, which could effectively improve the clinical symptoms of patients and reduce inflammatory reactions with less adverse drug reactions.