Abstract:OBJECTIVE To investigate the incidence of colon polyps clinical characteristics, influencing factors, to raise awareness of co⁃ lon polyps, colon polyps do the screening, better prevention and treatment of colon polyps. METHODS January 2017-June 2019, 180 cases of clinically diagnosed as colon polyps study observation group, selected 180 cases in another hospital in the same period of healthy normal population study as the control group. Comparison of two groups were age, gender, blood biochemical indicators were given. RESULTS There were male ratio was 66.67%，was significantly higher than 55.56%，χ2=4.68，P=0.03; mean age was ob⁃ served（62.57±4.81）years, significantly greater than in the control group（50.93±5.24）years，t=21.96, P=0.00. Observation group of Helicobacter pylori（HP）infection, smoking history was significantly higher in the observation group total cholesterol（TC）, triglyceride （TG）, low density lipoprotein（LDL）, CEA levels were significantly higher in high density lipoprotein（HDL）levels were significantly lower than the control group. Observation group type 2 diabetes, hypertension, family history of cancer, cholecystectomy was signifi⁃ cantly higher， Multivariate Logistic regression analysis found that age, HP infection, smoking, high blood pressure, TG level，CEA level of incidence of colon polyps independent risk factor. CONCLUSION The incidence of colon polyps many factors, such as older, HP infection and TG levels higher,so should pay attention to clinical risk factors for colon cancer, strengthen propaganda and guid⁃ ance, in order to better guide prevention and treatment of colon polyps reasonable people.