Abstract:OBJECTIVE To explore the clinical efficacy of adjusting oral hypoglycemic agents and switching to subcutaneous in⁃ sulin injection regimen in elderly patients with non-severe community-acquired pneumonia METHODS A total of 293 eligible pa⁃ tients admitted from January 2017 to December 2019 were randomly divided into oral hypoglycemic group (146 cases) and insulin treatment group (147 cases). All patients were given anti-infection treatment, one group adjusted oral hypoglycemic drugs to keep blood sugar under control, while another by subcutaneous injection of insulin. Antipyretic time, bacterial clearance rate, conversion, severe lung CT absorption rate, inflammation index, average blood sugar, blood glucose instability index, incidence of hypoglycemia were compared between two groups. RESULTS Compared with oral hypoglycemic drugs group, patients who accepted insulin injec⁃ tion had shorter antipyretic time, higher bacterial clearance, lower severe rate, better CT absorption ,better and smooth blood glucose control. The incidence of hypoglycemia and inflammation index improvement were no statistical difference between two groups. CON⁃ CLUSION For elderly diabetic patients with non-severe community-acquired pneumonia accepted oral hypoglycemic drugs but in poor glycemic switch to subcutaneous injections of insulin to control blood glucose got better control of infection and glycemic, while didn’ Key words: t increase the risk of hypoglycemia occurs. It could be a kind of optimization of clinical strategies.