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中文摘要: 目的：探讨鼠神经生长因子干预早产儿脑损伤的临床疗效及预后评估。方法：回顾性分析2016年1月—2018年
12月某院儿科门诊就诊的98例早产儿脑损伤患儿的临床资料，随机分为干预组和对照组，每组49人，对照组进行常规治疗
口服脑蛋白口服液+赖氨肌醇B12口服液，干预组给予鼠神经生长因子 （mouse nerve growth factor，mNGF） 18 μg+生理盐水2
ml肌注，隔日 1 次，每个疗程1个月，连续治疗3个疗程，比较两组治疗后临床有效率及智力运动发育评估 （Children, s De⁃
velopment Center of China, CDCC） 评分结果。 结果：CDCC评分结果显示干预组总有效率为 89.8%，高于对照组的 73.5%，差 异有统计学意义 （χ2=4.356，P＜0.05）；疗程结束后CDCC评分结果比较，干预组仍高于对照组，差异有统计学意义 （t值分
别为10.927、4.309，P值均＜0.05）；随访至纠正胎龄1岁时CDCC评分比较，干预组亦高于对照组，差异有统计学意义 （t值
分别为 10.013、3.238，P值均＜0.05）。结论：应用 mNGF单药早期干预早产儿脑损伤，可加快患儿症状改善，促进神经功
能恢复，疗效肯定，且经济方便，可减轻患者家属的经济负担，临床值得推广。
Abstract:OBJECTIVE To investigate the clinical effect and prognosis of mouse nerve growth factor (mNGF) on premature in⁃
fants with brain injury. METHODS Clinical data of 98 cases of premature infants with brain injury from January 2016 to December
2018 at pediatric clinic were analyzed and randomly divided into intervention group and control group. There were 49 cases in each
group. In the control group, oral cerebroprotein hydrolystate oral solution, and lysine, inosite and vitamin B12 oral solution were?
treated. The intervention group received?injection with mouse nerve growth factor (mNGF) in 18 ug + 2 ml saline, once every other
day, one month per course. The clinical effective rate and Children, Development Center of China (CDCC) scores of the two groups
were compared after 3 consecutive courses. RESULTS The total effective rate of the intervention group (89.8%) was higher than that
of the control group (73.5%) with statistically significant difference (χ2=4.356, P＜0.05). After the end of treatment compared CDCC
score, the intervention group was also higher than that of the control group, significant statistically was founded (t=10.927, 4.309, P＜ 0.05). Following up to correct gestational age to 1 year old, CDCC score was compared between two group with statistically signifi⁃
cant difference (10.013, 3.238, P＜0.05). CONCLUSION The efficacy of early intervention of mNGF in premature with brain injury
was positive, economical and convenient, and could reduce the economic burden on patients’ families. Therefore, it was worthy of
clinical promotion.
文章编号：3202108026 中图分类号：R742，R174 文献标志码：
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