Abstract:Abstract: OBJECTIVE To investigate the effect of intermittent pneumatic compression device after operation for senile endome⁃ trial carcinoma (UCEC) and its mechanism on blood flow velocity and coagulation function of lower limb veins. METHODS A total of 123 elderly patients undergoing UCEC surgical treatment in our department from January of 2021 to January of 2023 were selected and divided into control group and observation group according to random number table method. In the control group, 61 patients re⁃ ceived perioperative management based on the concept model of rapid rehabilitation surgery, and in the observation group, 62 pa⁃ tients received intermittent aerated pressure pump (IPCD). The incidence of DVT, lower limb venous blood flow velocity, lower limb swelling degree and coagulation index were compared between the two groups. RESULTS After intervention, the incidence of DVT in the observation group was 8.06% lower than 21.31% in the control group (χ2 =4.319, P＜0.05). The blood flow velocity of the external iliac vein, femoral vein and popliteal vein in the lower limb of the observation group was greater than that of the control group (t=-4.491, -3.752, -4.769, P＜0.05), and the circumference diameter of the thigh and leg in the observation group were smaller than that of the control group (t=6.568, 3.953, P＜0.05). The levels of D-dimer and plasma fibrinogen in observation group were lower than those in control group, and the prothrombin time and activated partial thromboplastin time in observation group were longer than those in control group (t=4.799, 5.713, 2.019, 3.247, P＜0.05). CONCLUSION IPCD is helpful to improve blood hypercoagulabil⁃ ity in elderly UCEC patients, speed up lower limb blood flow, improve lower limb edema, and effectively prevent DVT, which has clinical promotion value.