Abstract:Abstract: OBJECTIVE To analyze the phased implementation outcomes ofthe syphilis elimination program in Wuxi from 2019 to 2024,providing scientific evidence for refining measures to eliminate mother-to-child transmission of syphilis.METHODS Data on syphilis transmission prevention among infected pregnant women in Wuxi from 2019 to 2024 were collected from the National Management Information System for Prevention of Mother-to-Child Transmission of HIV,Syphilis,and Hepatitis B.Descriptive analysis was employed.RESULTS A cumulative total of 1,011syphilis-infected pregnant women were reported from 2019 to 2024.The proportions diagnosed during pregnancy and in early pregnancy increased annually.The syphilis testing rate among spouses/sexual partners of pregnant women was 66.77%,showing an upward trend over the years.The syphilis testing rate among women giving birth was 100.00%, with a positive rate fluctuating between 0.26%and 0.33%.The proportion of women receiving only intrapartum syphilis testing showed a declining trend over the years.Treatment rates for syphilis-infected mothers reached 97.36%,with standardized treatment rates at 82.32%.Prophylactic treatment rates for their infants reached 85.49%,all showing upward trends over time.Among 566 syphilis- exposed children who reached 21 months of age,the follow-up success rate was 79.33%.The incidence rate of congenital syphilis was 7.91 per 100,000.CONCLUSION Wuxi has continuously improvedin the quality of transmision prevention efforts.However,key areas requiring attention include syphilis infection management among migrant pregnant women and follow-up of syphilis-exposed children.