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中文摘要: 目的 探讨生长分化因子-15 (GDF-15)、M 型磷脂酶 A2 受体(PLA2R)及血清膀胱抑素C (CysC)在2型糖尿病肾病早期诊断中的价值。方法 选取于我院2013年12月—2016年3月就诊的2型糖尿病患者120例，根据其24 h尿微量白蛋白（mAlb）水平分为正常白蛋白尿组（A组）、微量白蛋白尿组（B组）及大量白蛋白尿组（C组），每组患者均为40例。分别对三组患者GDF-15、PLA2R及CysC水平进行检测，探讨临床2型糖尿病肾病早期诊断中的应用价值。结果 A组患者GDF-15、PLA2R及CysC指标水平依次低于B组、C组，存在显著差异（P＜0.05）；三组患者GDF-15、PLA2R、CysC指标水平组间对比差异显著（P＜0.05）；经ROC曲线分析，临床早期诊断2型糖尿病肾病中GDF-15、PLA2R和CysC指标均存在应用价值。结论 GDF-15、PLA2R及Cysc指标可作为临床早期诊断2型糖尿病肾病的辅助指标，具有一定临床推广价值。
中文关键词: 生长分化因子-15 M 型磷脂酶 A2 受体 血清膀胱抑素C 2型糖尿病肾病
Abstract:OBJECTIVE To explore the value of GDF-15, PLA2R and CysC in early diagnosis of type-2 diabetic nephropathy. METHODS 120 cases of patients with type-2 diabetic nephropathy treated in our hospital from December 2013 to March 2016 were selected, and were divided into normal albuminuria group (group A), microalbuminuria group (group B) and massive albuminuria group (group C), 40 cases in each group. GDF-15, PLA2R and CysC levels were detected separately in the three groups, and application value was explored in early diagnosis of type-2 diabetic nephropathy. RESULTS GDF-15, PLA2R and CysC levels in group A were significantly lower than those in group B and group C (P < 0.05). There were significant differences in GDF-15, PLA2R, and CysC indicators levels between the groups in the three groups (P < 0.05). ROC curve analysis showed it existed clinical value of GDF-15, PLA2R and CysC indicators in early diagnosis of type-2 diabetic nephropathy. CONCLUSION GDF-15, PLA2R, Cysc indexes can be used as auxiliary indexes in early diagnosis of type-2 diabetic nephropathy. It has a certain clinical value.
keywords: Growth differentiation factor-15 Type M phospholipase A2 receptor Serum somatostatin C Type-2 diabetic nephropathy
文章编号：3201711037 中图分类号：R587.2 文献标志码：
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