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中文摘要: 目的 分析支气管肺炎患儿血清白细胞介素-6(IL-6)、C反应蛋白(CRP)及降钙素原(PCT)水平的变化及意义。方法 选取轻症支气管肺炎(轻症组)患儿35例，重症支气管肺炎(重症组)28例，以及健康儿童30例为对照组，比较3组血清IL-6、CRP和PCT水平，观察治疗前后轻、重症组患儿上述水平的变化，并分析IL-6、CRP和PCT水平的相关性。 结果 与对照组比较，轻、重症组血清IL-6、CRP和PCT水平明显升高(P＜0.01)，且重症组各项水平升高程度更为显著(P＜0.01)。轻、重症组治疗后血清IL-6、CRP和PCT水平较治疗前明显降低(P＜0.01)，且轻症组各水平显著低于重症组(P＜0.05)。相关性结果表明，支气管肺炎患儿血清IL-6水平与CRP、PCT呈明显正相关，CRP水平与PCT呈明显正相关(P＜0.01)。结论 IL-6、CRP和PCT可能共同参与小儿支气管肺炎的病理过程，对三者进行联合检测有助于病情判定及早期治疗。
Abstract:OBJECTIVE To analyze the changes and significance of serum interleukin-6 (IL-6), C-reactive protein (CRP) and procalcitonin (PCT) levels in children with bronchopneumonia. METHODS Thirty-five children with mild bronchopneumonia (mild group), 28 children with severe bronchopneumonia (severe group) and 30 healthy children (control group) were respectively collected. The levels of serum IL-6, CRP and PCT were compared among three groups, and those in mild and severe groups were observed post- and pre-treatment. The relationships among IL-6, CRP and PCT levels were also analyzed. RESULTS When compared with control group, the levels of serum IL-6, CRP and PCT went up dramatically in mild and severe groups (P＜0.01), and the increased degrees in severe group were more significant (P＜0.01). When compared with pre-treatment, the levels of serum IL-6, CRP and PCT in mild and severe groups decreased obviously (P＜0.01), and the decreased degrees in mild group were more significant (P＜0.05). Correlation results revealed that in children with bronchopneumonia, the level of IL-6 was positively correlated with those of CRP and PCT, and the level of serum CRP was also correlated with PCT positively (P＜0.01). CONCLUSION IL-6, CRP and PCT may all involve in the pathological process of infantile bronchopneumonia, so their combined detection may be conductive to disease assessment and early treatment.
文章编号：3201801036 中图分类号：R563.1+2 文献标志码：
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