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中文摘要: 的 探究张掖市不同民族H型高血压伴2型糖尿病患者血清同型半胱氨酸（Hcy）、糖化血红蛋白水平（HbA1C）与颈动脉硬化的相关性。方法 选取张掖市人民医院收治的H型高血压伴2型糖尿病患者106例；分别根据动脉硬化程度及血压等级进行分组；并分析不同民族、不同颈动脉硬化程度和不同血压等级患者血清Hcy水平、HbA1C水平、颈动脉内膜中层厚度（cIMT）、叶酸、血肌酐和胆固醇；并分析血清Hcy水平、HbA1C水平、血压水平与cIMT的关系。结果 裕固族Hcy、HbA1C和cIMT均高于汉族（P＜0.05），叶酸低于汉族（P＜0.05）；3组不同动脉硬化程度患者Hcy水平、HbA1C水平、叶酸、血肌酐、胆固醇和cIMT相比差异有统计学意义（P＜0.05），cIMT增厚组高于cIMT正常组，颈动脉斑块组高于cIMT增厚组和cIMT正常组（P＜0.05）；3组不同血压等级患者Hcy水平、HbA1C水平、血肌酐、胆固醇和cIMT相比差异有统计学意义（P＜0.05），高血压2级组高于1级组，高血压3级组高于2级组和1级组（P＜0.05）；Hcy、HbA1C、收缩压、舒张压与cIMT呈正相关（r分别=0.495、0.692、0.421和0.501，P均＜0.05）。结论 裕固族患者cIMT增厚程度高于汉族患者，Hcy、HbA1C、血压与颈动脉硬化程度密切相关，Hcy、HbA1C、收缩压是影响cIMT的独立危险因素。
Abstract:Objective To explore the serum homocysteine (Hcy), glycosylated hemoglobin (HbA1C) changes in different ethnic patients with type H hypertension combined type 2 diabetic at Zhangye city and its correlation with carotid atherosclerosis. Methods Selected One hundred and six patients at Zhangye city with type H hypertension complicated type 2 diabetes in our hospital; According to the extent of arteriosclerosis and blood pressure levels were grouped; analyzed the levels of serum Hcy, HbA1C, carotid intima-media thickness (cIMT), folic acid, creatinine and cholesterol in different nationalities, different degrees of carotid atherosclerosis and different grades of blood pressure; the relationship between serum Hcy level, HbA1C level, blood pressure level and cIMT was analyzed. ResultS The Hcy, HbA1C and cIMT levels of Yugu nationality were significantly higher than that of the Han nationality (P＜0.05), folic acid level is lower than Han nationality (P＜0.05); there were significant differences in the levels of Hcy, HbA1C, folic acid, serum creatinine, cholesterol and cIMT between the three groups patients with different degrees of arteriosclerosis (P＜ 0.05), the cIMT thickening group was higher than the cIMT normal group, and the carotid plaque group was higher than that cIMT thickening group and cIMT normal group (P＜0.05); there were significant differences in the levels of Hcy, HbA1C, serum creatinine, cholesterol and cIMT between the three groups patients with different degrees of blood pressure (P＜0.05), hypertension grade 2 group was higher than the grade 1 group, hypertension grade 3 group was higher than the grade 2 group and grade 1 group P＜(0.05); Hcy, HbA1C, systolic blood pressure and diastolic blood pressure were positively correlated with cIMT (R=0.495, 0.692, 0.421, 0.501, P＜0.05). Conclusion The cIMT thickening degree of Yugu nationality patients is higher than Han nationality patients, Hcy, HbA1C and blood pressure are closely related to the degree of carotid atherosclerosis, Hcy, HbA1C and systolic blood pressure were independent risk factors for cIMT.
keywords: type h hypertension type 2 diabetes yugu nationality han nationality homocysteine glycosylated hemoglobin carotid atherosclerosis carotid intima-media thickness
文章编号：3201809034 中图分类号：R1-9 文献标志码：
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