Abstract:Objective To investigate the effects of different anesthesia methods on POCD, IL-6, TNF-α and S-100β protein in order to provide a reference for the prevention of POCD. Methods A total of 72 patients aged 60～72 years with ASA grade I-III were enrolled in our hospital from June 2014 to December 2016 under general anesthesia for esophageal cancer radical surgery. Patients were randomly divided into two groups: total intravenous anesthesia group (T group) and intravenous inhalational anesthesia group (group I), each group of 36 patients. MMSE score, MoCA score, S-100β, Interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) at 1 day before operation (T0), 1 day after operation (T1), 3 days after operation (T3) and 7 days after surgery (T7). Results MMSE score and MoCA score were significantly higher in the patients with intravenous anesthesia than those in the combined anesthesia group (P＜0.05) at 1 day, 3 days and 7 days after cognitive function score. IL-6, TNF-α and S-100β were significantly lower than those in the combined anesthesia group (P＜0.05). The levels of IL-6, TNF-α and S-100β were significantly lower in the patients with intravenous anesthesia. Conclusion Compared with intravenous anesthesia, the incidence of POCD in elderly patients undergoingesophageal cancer radical surgery with intravenous anesthesia was lower, and the concentrations of IL-6, TNF-α and S-100β were increased in patients with POCD. Total intravenous anesthesia in such patients is worthy of promotion.