Abstract:OBJECTIVE To explore the influencing factors and the main involvement system in patients with hypertension complicated by osteoporosis, thus providing scientific basis for prevention and treatment of hypertension with osteoporosis. METHODS The elderly who underwent a physical examination at Lingqiao Community Health Service Center in Pudong New Area in 2017 were selected as the study subjects. The physical examination items included physical examination, blood pressure level, blood biochemical indicators, etc. The bone mineral density(BMD) was measured by dual energy X-ray absorptiometry, and the living habits of the subjects were investigated by interview. RESULTS 3 965 subjects were included in the study. The multiple logistic regression analysis indicated that aged 60～69 (OR=0.466, 95%CI 0.239～0.909) was protective factor of normal blood pressure and no osteoporosis. BMI<24 kg/m2(OR=1.668, 95%CI 1.181～2.357) was risk factor. Male(OR=0.618, 95%CI 0.393～0.971), aged 60~69 (OR=0.421, 95%CI 0.210～0.844) were protective factors of normal blood by osteoporosis. BMI<24 kg/m2(OR=1.617, 95%CI 1.119～2.337) was risk factor of normal blood by osteoporosis. Factor analysis and logistic regression analysis indicated that the changes of physiological and biochemical indexes of urinary system were closely related to hypertension complicated by osteoporosis. CONCLUSION Health education should be strengthened, bone mineral density and blood pressure should be closely monitored, and the elderly should be encouraged to exercise, eat properly, maintain a proper weight and make early prevention.