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中文摘要: 目的 探讨药学服务应用于乳癌患者辅助内分泌治疗中的效果。方法 选取2017年1月—2017年9月期间的34例乳癌术后内分泌治疗患者为对照组（未实施临床药学服务），2017年10月～2018年6月期间的36例患者为观察组（实施临床药学服务）。比较两组患者的不良反应发生率、特定指标复查率和用药依从性。结果 观察组的不良反应发生率低于对照组（30.56% vs70.59%，χ2=11.209，P=0.001），妇检复查率高于对照组（100% vs53.33%，χ2=11.165，P=0.001），骨密度检查复查率高于对照组（100% vs57.89%，χ2=9.203，P=0.002），血常规和肝功能检查复查率高于对照组（100% vs61.76%，χ2=16.904，P=0.001），用药依从性高于对照组（100% vs73.53%，χ2=10.935，P=0.001）。结论 临床药师参与乳腺癌辅助内分泌治疗，有助于减少用物后的不良反应率，提高特定指标复查率，改善用药的依从性。
Abstract:OBJECTIVE To explore the effect of pharmaceutical services in adjuvant endocrine therapy for breast cancer patients. METHODS From January 2017 to September 2017, 34 patients with endocrine therapy for breast cancer were selected as the control group (no clinical pharmacy service). 36 patients from October 2017 to June 2018 were the observation group(implement clinical pharmacy services). The incidence of adverse reactions, the rate of review of specific indicators and medication adherence were compared. RESULTS The incidence of adverse reactions in the observation group was significantly lower than the control group (30.56% vs 70.59%, χ2=11.209, P=0.001). The gynecological examination rate of the observation group was higher than the control group (100% vs 53.33%, χ2=11.165, P=0.001), and the bone mineral density examination review rate was higher than the control group (100% vs 57.89%, χ2=9.203, P=0.002), the blood routine and liver function test review rate was higher than the control group (100% vs 61.76%, χ2=16.904, P=0.001). The medication compliance of the observation group was higher than the control group (100% vs 73.53%, χ2=10.935, P=0.001). CONCLUSION Clinical pharmacists involved in breast cancer adjuvant endocrine therapy could help reduce the adverse reaction rate after use, improve the review rate of specific indicators, improve medication compliance, and promote the rational use of endocrine therapy after breast cancer surgery.
文章编号：3201907027 中图分类号：R737.9 文献标志码：
基金项目:
| 作者 | 单位 |
| 李 锦①, 张 迎 ② |
| Author Name | Affiliation |
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