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中文摘要: 目的 探究吡格列酮联合二甲双胍治疗2型糖尿病(T2DM)合并代谢综合征(MS)的临床疗效。方法 回顾性分析甘肃省庆阳市人民医院给予二甲双胍（对照组）及联合吡格列酮（观察组）治疗的T2DM合并MS患者各42例临床资料。评估糖代谢[空腹血糖(FPG)、餐后2 h血糖(2hPG)和糖化血红蛋白(HbA1c)]；脂代谢[甘油三酯(TG)、胆固醇(TC)]；胰岛β细胞功能[胰岛β细胞功能指数(HOMA-β)]、胰岛素抵抗[稳态模型胰岛素抵抗指数(HOMA-IR)]及肾损伤[尿白蛋白排泄率(UAER)、同型半胱氨酸血症(Hcy)]情况。结果 治疗12周后，两组FPG、2hPG、HbA1c、TG、TC、HOMA-IR、UAER和Hcy均较治疗前降低，且观察组低于对照组；HOMA-β较治疗前升高，且观察组高于对照组（均P＜0.05）。结论 两者联合治疗T2DM并MS效果显著，临床应用价值高。
Abstract:OBJECTIVE To explore the clinical efficacy of pioglitazone combined with metformin on type 2 diabetes mellitus (T2DM) with metabolic syndrome (MS). METHODS The clinical data of each 42 patients with T2DM and MS who were treated with metformin (control group) or combination of pioglitazone (observation group) in target hospital were retrospectively analyzed. The glucose metabolism [fasting plasma glucose (FPG), postprandial 2h blood glucose (2hPG), glycosylated hemoglobin (HbA1c)], lipid metabolism [triglyceride (TG), cholesterol (TC)], islet β-cell function [islet β-cell function index (HOMA-β)], insulin resistance [homeostasis model assessment of insulin resistance (HOMA-IR)] and renal injury [urinary albumin excretion rate (UAER), homocysteineemia (Hcy)] were evaluated. RESULTS After 12 weeks of treatment, the FPG, 2hPG, HbA1c, TG, TC,HOMA-IR, UAER and Hcy in these two groups were decreased compared with those before treatment, and the above indexes in observation group were lower than the control group. The HOMA-β was higher than that before treatment, and the index in observation group was higher than the control group (all P＜0.05). CONCLUSION The combination of these two groups had significant effects and high clinical application value in the treatment of T2DM with MS.
keywords: pioglitazone metformin T2DM MS
文章编号：3201909033 中图分类号：R587.1 文献标志码：
基金项目:
| 作者 | 单位 |
| 张玉媛①，田珺灵② |
| Author Name | Affiliation |
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