Abstract:OBJECTIVE To analyze and evaluate the pilot operation of multi-sectoral cooperation in immunization program for migrant children, and provide basis for continuing to improve the detection rate of migrant children and the immunization level. METHODS In the project of immunization program promotion for migrant children in cooperation with UNICEF,the mechanism of detection and referral of migrant children was established Nanhai District, Foshan. On this basis, 311 grass-roots preventive workers and 342 village-level floating population managers were divided into two groups by questionnaire survey. EpiData Software 3.0 was used to input the survey data, and SPSS software was used to make statistical analysis. RESULTS 65% of the staff engaged in vaccination work, more than 50% of them took part in other jobs at the same time; 83.8% of the preventive health workers used mobile phone text messages, and most of them improved the vaccination rate of migrant children by checking leaks in the countryside, issuing notifications to the neighborhood committee, and according to the list of migrant children provided by the neighborhood committee. Most of the managers of migrant population found migrant children through inspections, and worked on on-site registration and distribution of contact cards or registration of migrant children in the “register of migrant children”. Most of the two groups found migrant children during leak detection in the countryside, while there were differents in finding the migrant children based on the registration of migrant children and the birth data provided by the family planning department between the two groups (χ2 were 3.92 and 5.21, respectively, P<0.05). 38% of the population reported that there were fewer and fewer migrant children. 76.8% of the preventive health workers and 56.8 % of the managers of the migrant population thought that their parents did not cooperate (χ2=24.8, P<0.01). Nearly 60% of the staff in both groups thought that there were too many other jobs and hard to take the work (χ2=0.41, P>0.05). It was generally believed that the effective measures to improve the detection rate of migrant children were to increase incentives, rationally distribute incentives and simplify the process. CONCLUSION The migrant children detection and referral mechanism section established in the implementation stage of the project could effectively identify migrant children and improve their immunization coverage rate. It was necessary to obtain funds to ensure the long-term and sustainable operation of the mechanism.