Abstract:OBJECTIVE To study the effect of WeChat platform based self-management intervention on pulmonary function and quality of life in COPD patients. METHODS 80 cases of COPD patients who treated in target hospital from January 2017 to December 2018 were selected and divided into control group and observation group by random number table method, 40 cases in each group. Patients in the control group were self-managed by referring to COPD self-management knowledge manual, while patients in the observation group were self-managed by using WeChat platform. Lung function, quality of life, anxiety, depression and exercise endurance were compared between these two groups. RESULTS The scores of FEV1, FEV1/FVC, 6MWD and Borg in the two groups were similar be⁃ fore treatment（P＞0.05）, but improved significantly after treatment, moreover, the levels of FEV1, FEV1/FVC and 6MWD in the ob⁃ servation group were higher than the control group, and the Borg score was lower than the control group（P＜0.05）. After treatment, the respiratory symptoms, activity restriction, disease influence and SGRQ score of the observation group were lower than those in the control group（P＜0.05）. Before treatment, the HAD score and SDS score of these two groups were similar（P＞0.05）. However, the HAD score and SDS score of the observation group were lower than the control group after treatment（P＜0.05）. CONCLUSION Self-management intervention based on WeChat platform could significantly improve pulmonary function, exercise endurance and qual⁃ ity of life in COPD patients, relieve their anxiety and depression and symptom of dyspnea, which was widely recommended in clinical application.