Abstract:OBJECTIVE To explore the nursing effect of clinical nursing pathway applied to the patients with lung cancer during perioperative period. METHODS 105 cases of patients with lung cancer who underwent surgery in the hospital from September 2017 to September 2019 were selected as the research objects. The patients were divided into the control group（n=52）and the observa⁃ tion group（n=53）by random number method. The control group was given routine nursing models such as daily life nursing，medi⁃ cation guidance and popular science education，and the observation group was given the clinical nursing pathway. The hospitaliza⁃ tion time，the hospitalization expenses，the incidence of complications，the mastery of disease-related knowledge，nursing efficien⁃ cy and nursing satisfaction between the two groups were compared. RESULTS The hospitalization time，hospitalization expenses and incidence of complications of the observation group were lower than those of the control group，differences were significant，the val⁃ ues of t were 7.601， 11.141， 9.934， P＜0.05. The total mastery rate of disease-related knowledge in the observation group （96.23%） was higher than that in the control group（67.31%）（χ2=14.811，P＜0.05）. The total effective rate of nursing care in the observation group（96.23%）was higher than that in the control group（73.08%）（χ2=10.890，P＜0.05）. The total satisfaction of nursing care in the observation group（92.45%）was higher than that in the control group（63.46%）（χ2=12.896，P＜0.05）. CON⁃ CLUSION The clinical nursing pathway had a significant effect in the nursing of patients with lung cancer during the perioperative period. It could shorten the hospitalization time，save hospitalization expenses，reduce incidence of complications，increase the mastery of disease-related knowledge，and improve nursing effect and nursing satisfaction，which was worthy of clinical promotion.