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中文摘要: ：目的：探讨吸烟和饮酒及其交互作用对糖尿病发病的影响。方法：研究数据为中国瑞慈医疗集团2010—2016年所
有体检者的医疗记录。利用此数据进行回顾性队列研究。通过问卷调查进行资料收集，包括基本情况调查、身体测量和生化
指标检测3个部分。采用相乘模型和相加模型分析吸烟与饮酒及其交互作用对糖尿病发病的影响。结果：根据筛选标准纳入
60 230人，中位随访时间为2.99年，其中1 172人发生糖尿病。经多因素校正后，吸烟会增加糖尿病的发病风险 （HR=1.52， P＜0.01）。结论：吸烟会增加糖尿病的发病风险，现有证据未发现饮酒会增加糖尿病发病风险，饮酒也未增加吸烟对糖尿病
发病的风险。戒烟、戒酒及其交互作用也未降低糖尿病发病的风险。
Abstract:OBJECTIVE To explore the influences of smoking，drinking and their interactions on the diabetes. METHODS The
data was the medical records of all the medical examiners from Rich Healthcare Group of China from 2010 to 2016. The data was
used to conduct a retrospective cohort study. Data collection was conducted through questionnaire surveys including three parts：sur⁃
veys on basic situation，physical measurement，and biochemical indicator testing. The multiplicative model and the additive model
were used to analyze the influence of smoking，drinking and their interactions on the diabetes. RESULTS According to the screening
criteria，60 230 people were enrolled. The median follow-up time was 2.99 years. 1 172 people suffered from diabetes among them.
After adding multi-factor adjustment，smoking increased the risk of diabetes （HR=1.52，P＜0.01）. CONCLUSION Smoking in⁃
creased the risk of diabetes. Existing evidence did not find that drinking increased the risk of diabetes. Drinking did not increase the
risk of smoking-caused diabetes. Stopping smoking or alcohol and their interactions also could not reduce the risk of diabetes.
文章编号：3202108008 中图分类号：R587.1 文献标志码：
基金项目:
| 作者 | 单位 |
| 王新月1，贾胜1，高键2 |
| Author Name | Affiliation |
引用文本：