Abstract:Abstract: OBJECTIVE To investigate the risk factors of H. pylori reinfection in the community population, and to construct an optimal plan for eradication treatment and analyze the treatment effect. METHODS From July to December 2022, 472 patients with positive helicobacter pylori infection who received treatment in Shanghai Gaohang Community Health Service Center were selected in a randomized, double-blind method. After 2 weeks of standardized treatment, a total of 116 patients with positive helicobacter py⁃ lori infection who met the criteria and turned negative were detected. They were divided into control group (58 cases) and interven⁃ tion group (58 cases) according to random number table method. Patients in the control group were not given any intervention, and family doctors in the intervention group were given community intervention after recovery, including diet, living habits, medication guidance and supervision for chronic diseases. To evaluate the re-infection of helicobacter pylori in the patients within half a year af⁃ ter they turned negative. RESULTS After intervention, there were 2 cases of helicobacter pylori reinfection in the intervention group, and the eradication rate was 96.55% (56/58). In the control group, 27 patients were reinfected with Helicobacter pylori, and the erad⁃ ication rate of helicobacter pylori was 53.45% (31/58). There was significant difference in the eradication rate of Helicobacter pylori between the intervention group and the control group (χ2 =28.736, P＜0.05). The results showed that the influence of immediate fami⁃ ly education, brushing frequency, upper digestive tract disease history, drinking history and fresh fruit consumption frequency on He⁃ licobacter pylori reinfection was significant. The difference was statistically significant (χ2 =4.647, 7.302, 4.296, 4.494, 6.121, respec⁃ tively, P＜0.05). logistic regression analysis showed that the risk factors of H. pylori reinfection were immediate family members with junior high school education or below, no teeth brushing, history of upper digestive tract disease, drinking history and never eating fresh fruit. CONCLUSION Quadruple therapy combined with the community intervention of family doctor team and the development of good medical behavior are more effective for the eradication of Helicobacter pylori reinfection.