Abstract:Abstract: OBJECTIVE To explore the association between CRP, IL-6, and IL-8 levels and newly screened patients with COPD. METHODS From August to October 2022, blood samples were collected from 248 COPD patients and 248 randomly selected non-COPD residents from the Shanghai Suburban Adult Cohort and Biobank who had undertaken a spirometry test and question⁃ naire survey. Serum CRP, IL-6, and IL-8 levels were measured for further analysis. The cut-off points for CRP were based on the absence of inflammatory risk and the normal reference range; for IL-6 and IL-8 were based on the lower detection limits and the normal reference range. Multinomial logistics regression was used to evaluate the association between serum inflammatory makers and COPD, and multiple linear regression was used to evaluate the impact on lung function. RESULTS 207 COPD patients and 218 non-COPD residents were finally included. In 8.9%, 5.4%, and 9.6% of the participants, respectively, the serum CRP, IL-6, and IL-8 concentrations were outside the normal reference range. Multivariable analysis showed that CRP>1 mg/L was a risk factor for COPD. In COPD patients with CRP≥5 mg/L, there was a negative correlation between CRP and lung function. IL-6 and IL-8 were not associated with COPD and lung function in this population. CONCLUSION COPD might be a chronic systemic inflammatory dis⁃ ease. Compared to IL-6 and IL-8, serum CRP performed better in predicting the risk of COPD and lung function decline. Early screening for COPD is needed in people with chronic CRP levels above 1 mg/L.