Abstract:Abstract: OBJECTIVE To analyze the epidemic characteristics and pathogenic spectrum changes of hand, foot and mouth disease in Qingpu District from 2013 to 2023,and provide scientific basis for formulating prevention and control strategies. METHODS Hand, foot and mouth disease cases and pathogen surveillance data in Qingpu District were collected through the National Disease Prevention and Control Information System and pathogen surveillance reports over the years, and descriptive epidemiological methods were used to analyze the three-dimensional distribution characteristics and pathogen surveillance results. RESULTS The average annual incidence rate of Qingpu District from 2013 to 2023 was 156.33/10 5 ,and the incidence rate showed an overall downward trend (χ 2 =4314.73, P<0.01). There were double peaks from 2013 to 2017 (April to July, October to December),with the summer peak shifting backward from 2016 to 2017 (June to July),single peaks (June to October) in 2018, 2019,and 2023,and continued low incidence from 2020 to 2022. The order of regional incidence rates is Qingdong area>urban area>Qingxi area. The age distribution is mainly among children aged 5 and below,accounting for 87.17%. The main population is classified as scattered children accounting for 58.57%,kindergarten children accounting for 31.63%,and students accounting for 9.16% , with statistically significant differences (χ 2 =1086.80, P<0.01). In 2023, the proportion of students exceeded that of kindergarten children. The positive rate of CoxA 6 detection increased as the dominant pathogen (χ 2 =80.48, P<0.01). CONCLUSION June to October is the peak period for the incidence of hand, foot and mouth disease in Qingpu District. It is necessary to strengthen the prevention and control of hand,foot and mouth disease in children under 5 years old,kindergartens, and schools, especially in the Qingdong area and urban areas. Strengthening pathogen monitoring can help grasp the epidemic characteristics of hand,foot and mouth disease.