Abstract:Abstract: OBJECTIVE To investigate and trace the source of mixed-factor foodborne disease outbreak events, discover and explore its characteristics, and provide reference for the study of similar events. METHODS Through epidemiology, food hygiene and laboratory testing and pulsed field gel electrophoresis (PFGE) technology. RESULTS 85 cases were confirmed, with the incidence rate of 11.7% (85/727) cases, salmonella Dublin was detected in 12 patient stool specimens and 2 anal swabs from hotel staff , and PFGE method determine the homology; rotavirus group in environmental samples, cleaning water, reservoir water, sample food and stool samples of some cases. CONCLUSION The incident was an outbreak of a foodborne illness caused by Salmonella in Dublin, food for transmitting the disease is unknown, the source of the infection came from the hotel staff. Co-existing high-risk factors: group A rotavirus, it originates from the secondary water supply. It is suggested that the relevant regulatory authorities should strengthen the supervision of catering and secondary water supply units, including people working in non-contact ready-to-eat food products into health management, add a monitoring mechanism for secondary water supply, to prevent such incidents from happening again.