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中文摘要: 摘 要：目的：了解2019—2024年重庆市九龙坡区出生队列儿童13价肺炎球菌结合疫苗(13-Valent Pneumococcal Polysaccharide Conjugate Vaccine,PCV13) 接种率，以及疑似预防接种异常反应 (Adverse Event Folowing Immunization, AEFI) 报告发生情况。方法：基于重庆市免疫规划信息管理系统和中国疾病预防控制信息系统收集2019—2024年九龙坡区 出生儿童接种信息和AEFI 监测信息，采用SPSS 22.0软件对数据进行统计分析。结果：2019—2024年九龙坡区出生队列儿童 PCV13第1、2、3、4剂次接种率分别为24.33%~39.09%、21.97%~35.22%、20.99%~27.22%和18.98%~6.57%,2019—2022 年出生队列儿童各剂次接种率均呈上升趋势(P<0.05), 常住儿童、城区儿童各剂次接种率分别高于流动儿童、乡镇儿童。 AEFI总体报告发生率为69.79/10万剂，主要为一般反应，表现为发热、局部红肿和局部硬结。乡镇儿童及7~11月龄接种、 第2季度接种PCV13的儿童， AEFI 报告发生率相对更高。结论：2019—2024年九龙坡区出生队列儿童PCV13 总体接种率较 高，2019—2022年出生队列儿童各剂次接种率呈递增趋势， AEFI 报告发生率较低且以一般反应为主。应通过强化宣传、健 全流动儿童接种管理、加大乡镇资源投入提升接种率，针对高发人群与季节加强接种后随访，及时发现和处理不良反应。
中文关键词: 关键词：13价肺炎结合球菌疫苗 接种率 疑似预防接种异常反应
Abstract:Abstract: OBJECTIVE To understand the vaccination rates of 13-valent pneumococcal conjugate vaccine(PCV13)and the reporting incidence of adverse events following immunization(AEFI)in Jiulongpo District of Chongqing from 2019 to 2024.METHODS Based on the Immunization Program Information Management System in Chongqing and the Information System of the Chinese Center for Disease Control and Prevention,vaccination information and AEFI monitoring information of children borm from 2019 to 2024 were collected.And SPSS 22.0 software were usedfor analysis.RESULTS The vaccination rates of the first,second,third,and fourth doses of PCV13 for children in the birth cohort from 2019 to 2024 in Jiulongpo District of Chongqing were 24.33%-39.09%,21.97%-35.22%,
20.99%-27.22%and 18.98%-6.57%,respectively.The vaccination rates of each dose all showed the same trend of first increasing and then decreasing(P<0.05).The vacination rates of each dose for permanent resident children and children in urban areas were higher than those for migrant children and children in rural areas.The overall reported incidence rate of AEFI was 69.79/100,000 doses.The main types were general reactions,manifested as fever,local redness,sweling,and induration.The reported incidence rate of AEFI was relatively higher for children in rural areas,children vaccinated PCV13 at the age of 7-11 months,and those vaccinated in the second quarter.CONCLUSION The overall accination rate of PCV13 among children born from 2019 to 2024 in Jiulongpo District of Chongqing is relatively high,but the vaccination rate has shown a decreasing trend in the recent three years.The reported incidence of AEFI is low and mainly consists of general reactions.I is necessary to enhance publicity,improve the vaccination management for migrant children, and increase resource allcation in rural areas to boost vaccination rates.Additionally,targeted follow-ups should be strengthened for high-risk groups and during peak seasons to promptly identify and address adverse reactions.
keywords: Keywords: 13-valent pneumococcal conjugate vaccine vaccination rate adverse event following immunization
文章编号：3202410021 中图分类号：R186 文献标志码：
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