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中文摘要: 摘 要：目的：分析2005—2024年天津市宁河区疑似预防接种异常反应 (Adverse Events Following Immunization,AEFI) 监测数据，评价 AEFI 监测报告质量。方法：收集整理2005—2024年宁河区报告的常规使用疫苗(不含紧急使用和附条件上 市疫苗)AEFI个案数据，描述性分析AEFI 个案的发生特点和报告发生率。结果：2005—2024年宁河区共报告AEFI 个案995例， 报告发生率为40.96/10万；共报告不良反应982例，占AEFI 个案总数的98.69%,其中一般反应829例、异常反应153例； AEFI 发生与疫苗接种时间间隔主要为0~3天，占95.18%;995例AEFI 个案中，男、女性别比为1.16:1,0~1岁个案占总 数的70.95%;所报告的AEFI 个案，涉及31种疫苗，报告发生率最高的免疫规划疫苗是无细胞百白破疫苗(115.86/10万剂), 报告发生率最高的非免疫规划疫苗是乙脑灭活疫苗(153.84/10万剂);AEFI个案临床诊断以一般反应症状(发热/红肿/硬结) 为主，占79.20%,其次是过敏性皮疹；报告的995例AEFI 个案均已痊愈。结论：宁河区常规使用疫苗的预防接种安全性较高， AEFI 监测报告系统运转良好。
中文关键词: 关键词：疑似预防接种异常反应 疫苗 监测
Abstract:Abstract: OBJECTIVE To analyze adverse event following immunization(AEFI)surveillance data from Ninghe District of Tianjin Municipality,spanning from 2005 to 2024,to evaluate the quality of AEFI reporting.METHODS It collected and organized AEFI case data for routinely used vaccines(excluding emergency use and conditional marketing vaccines)reported in Ninghe District from 2005 to 2024,conducting descriptive analysis of AEFI occurrence patterns and reporting rates.RESULTS A total of 995 AEFI cases were reported in Ninghe District from 2005 to 2024,with a reporting rate of 40.96/100,000 cases.Among these,982 adverse reactions(98.69%of total AEFI cases)were reported,including 829 general reactions and 153 abnormal reactions.The majority of AEFI occurrences (95.18%) occurred within 0-3 days after vaccination.The gender ratio of 995 AEFI cases was 1.16:1,with 70.95%of cases occurring in children aged 0-1 years.The reported AEFI cases involved 31 vaccines.The most frequently reported immunization program vaccine was the acellular DTP vaccine(115.86/100,000 doses),while the most frequently reported non-immunization program vaccine was the inactivated JE vaccine (153.84/100,000 doses).The most common clinical diagnosis for AEFI was general reaction symptoms(fever/redness/hardness), accounting for 79.20%,followed by allergic rashes.All 995 reported AEFI cases have been resolved.CONCLUSION The vaccination program in Ninghe District is safe and reliable,with the AEFI monitoring and reporting system functioning properly.
文章编号：3202410022 中图分类号：R186 文献标志码：
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