本文已被：浏览 4614次 下载 0次
中文摘要: 摘 要：目的：分析2015—2024年安阳市殷都区疑似预防接种异常反应(adverse event following immunization,AEFI) 监测数据，为优化基层AEFI 监测系统提供实证依据。方法：AEFI 个案信息和接种剂次数据分别来源于我国AEFI 监测信息 管理系统及河南省免疫规划信息管理系统。采用SPSS 22.0软件对数据进行统计分析，采用SatScanv 10.0软件进行时空扫描 分析。结果：2015—2024年安阳市殷都区累计报告AEFI 3311例，年均报告发生率为99.49/10万，总体报告发生率呈上升 趋势(x²=42.43,P<0.05) 。AEFI 报告集中在5 — 9月，发现2个时空聚集区。男女性别比为1.05:1,以<1岁和1~4岁 儿童为主。AEFI 报告发生率一般反应为98.10/10万，异常反应为0.93/10万，偶合症为0.45/10万。从AEFI 接种到发生、发 生到就诊的时间间隔主要集中在48小时内。结论：2015—2024年安阳市殷都区AEFI 监测系统常规运行平稳，但存在应急 韧性不足、数据质量有待提升、监测网络不均衡的问题。建议通过构建应急机制、强化数据管理与精准督导，系统提升监测 效能。
中文关键词: 关键词：疑似预防接种异常反应 监测 分析 时空扫描 疫苗
Abstract:Abstract: OBJECTIVE To analyze and review the reported data of suspected AEFI in Yindu District of Ainyang from 2015 to 2024,and provide basis for optimizing the AEFI monitoring system at grasroots level.METHODS The dates of adverse events following immunization(AEFI)cases and vaccination doses were respectively collected via the China AEFIMonitoring Information Management System and the Henan Provincial Immunization Planning Information Management System.SPSS 22.0 was utilized for statistical data analysis,and spatio-temporal clustering analysis was conducted using SaTScan v10.0.Descriptive epidemiology was applied to characterize the study population.RESULTS From 2015 to 2024,a total of 3,311 cases of Adverse Events Following Immunization (AEFIs)were reported in Yudu District of Anyang,with an average annual reported incidence rate of 99.49 per 100,000.The overall reported incidence rate exhibited an upward trend(x²=42.43,P<0.05).AEFIS concentrated from May to September.Two spatiotemporal clusters were identified.The first cluster spanned from March 2018 to January 2020,encompassing 8 towns/communities; the second cluster was from March 2018 to July 2019,including 5 towns/communities.The male-to-female ratio was 1.05:1.Children aged<1 year and 1-4 years were the primary affected groups.The reported incidence rates ofAEFIs were 98.10 per 100,000 for general reactions,0.93 per 100,000 for abnormal reactions,and 0.45 per 100,000 for coincidental events.The differences in the incidence rates among general reactions,abnormal reactions,and coincidental events were statistically significant(x²=9,523.49,P<0.01). Thetime intervals from vaccination to the occurrence of AEFIs and from the occurrence to medical visits were predominantly within 48 hours.CONCLUSION From 2015 to 2024,the regular operation of AEFI surveillance system in Yindu District of Anyang remained stable.However,several issues emerged,including inadequate emergency response capabilities,the need for enhanced data quality, and an unbalanced surveillance network.It is recommended that the effectiveness of the surveillance be comprehensively enhanced by optimizing the emergency mechanism,strengthening data management,and implementing precise supervision.
keywords: Keywords: adverse events following immunization(AEFI) surveillance analysis spacetime scan vaccine
文章编号：3202410026 中图分类号：R186 文献标志码：
基金项目:
| 作者 | 单位 |
| 许 春 艳1, 胜 桂 红2 |
| Author Name | Affiliation |
引用文本：