Abstract:Abstract: OBJECTIVE To analyze the relationship and predictive value of blood pressure variability on early neurological dete⁃ rioration (END) in patients with acute ischemic stroke. METHODS 59 patients with acute ischemic stroke were selected and divided into the END group and non-END group based on the NIHSS score within 72 hours of admission. All subjects underwent 24-hour ambulatory blood pressure monitoring to record the mean value and coefficient of variation of blood pressure. General information and blood pressure variability indicators of the two groups were compared, and correlation analysis was performed. ROC curve analy⁃ sis was used to evaluate the predictive value of blood pressure variability indicators for END in acute ischemic stroke. RESULTS The average NIHSS score of patients admitted to hospital in the END group was (7.35±3.42) points, and the average NIHSS score of pa⁃ tients admitted to hospital in the END group was (5.07±2.76) points, and the average NIHSS score of patients admitted to hospital in the END group was significantly higher than that of patients admitted to hospital in the end group, with statistical significance (P＜ 0.05). The NIHSS score at admission was positively correlated with the coefficient of variation of 24-hour systolic blood pressure and 24-hour diastolic blood pressure (r＝0.325, 0.403, P＜0.05). ROC analysis showed that the area AUC under ROC curve of the END of acute cerebral infarction predicted by the coefficient of variation of 24-hour systolic blood pressure and 24-hour diastolic blood pressure was 0.706 and 0.634, respectively. CONCLUSION Blood pressure variability is closely related to early neurological deterio⁃ ration in acute ischemic stroke, and the coefficient of variation of systolic blood pressure at 24 hours can accurately predict the oc⁃ currence of END.