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中国初级卫生保健:2024,38(5):108-110
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氨氯地平联合依那普利治疗老年高血压疗效观察
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中文摘要: 摘 要:目的:观察苯磺酸氨氯地平片和马来酸依那普利片联合使用对老年高血压患者的治疗效果。方法:选取2019年 2月—2022年1月上海市浦东新区陆家嘴社区卫生服务中心诊治的150例老年高血压病患者,依据随机数字表法,将患者分 为对照组(n=75)和观察组(n=75)。给予观察组患者苯磺酸氨氯地平片和马来酸依那普利片联合治疗,给予对照组患者单 纯苯磺酸氨氯地平片进行治疗,治疗 8 周后,观察两组患者的药物疗效及安全性。结果:治疗后,观察组血压达标率 89.33%,高于对照组的72.00%,差异有统计学意义(χ2 =7.224,P<0.05);观察组患者收缩压、舒张压及平均动脉压水平均 明显低于对照组,差异均有统计学意义 (t值分别为9.029、8.229、7.719,P值均<0.05);观察组一氧化氮水平为 (39.54± 4.30)μmol/L,明显高于对照组的(33.84±4.17)μmol/L,差异有统计学意义(t=8.241,P<0.05);观察组血管紧张素Ⅱ、内 皮素水平分别为(50.19±7.13)ng/dl、(63.12±7.94)ng/L,明显低于对照组的(57.34±6.22)ng/dl、(74.85±8.83)ng/L,差异 均有统计学意义(t值分别为6.544、8.555,P值均<0.05)。对照组不良反应发生率为13.33%,明显高于观察组的4.00%,差 异有统计学意义 (χ2 =4.127,P<0.05)。结论:苯磺酸氨氯地平片和马来酸依那普利片联合治疗老年高血压患者能够实现协 同降压效果,可以显著改善患者血管活性物质,提高血压控制达标率,且其药物不良反应发生率、有效性及安全性明显优于 单独使用氨氯地平。
Abstract:Abstract:OBJECTIVE To analyse the effect and safety of Amlodiping combined with enalapril for elder patients with hypertension. METHODS A total of 150 elderly hypertensive patients diagnosed and treated in Lujiazui Community Health Service Center,Pudong New Area,Shanghai from February 2019 to January 2022 were selected and divided into control group (n=75) and observation group (n=75) according to random number table method. Observation group was given amlodipine besylate tablet and enalapril maleate tablet combined treatment,control group was given amlodipine besylate tablet alone treatment,after 8 weeks of treatment,the efficacy and safety of the two groups of patients were observed. RESULTS After treatment,the blood pressure of observation group reached the standard 89.33% , higher than that of control group 72.00% , the difference was statistically significant(χ2 =7.224,P<0.05). After treatment,the systolic blood pressure,diastolic blood pressure and mean arterial pressure in observation group were significantly lower than those in control group,and the differences were statistically significant(t=9.029, 8.229, 7.719, P<0.05). After treatment, the NO level in the observation group was (39.54 ± 4.30) μmol/L, which was significantly higher than that in the control group (33.84±4.17) μmol/L,and the difference was statistically significant(t=8.241, P<0.05). The levels of Ang Ⅱ and ET-1 in the observation group were (50.19 ± 7.13) ng/dl and (63.12 ± 7.94) ng/L, respectively,which were significantly lower than those in the control group (57.34 ± 6.22) ng/dl and (74.85 ± 8.83) ng/L, respectively. The differences were statistically significant (t=6.544, 8.555, P<0.05). The incidence of adverse reactions in control group was 13.33% , which was significantly higher than that in observation group (4.00%), and the difference was statistically significant (χ2 =4.127, P<0.05). CONCLUSION The combined use of amlodipine besylate tablets and enalapril maleate tablets can achieve synergistic antihypertensive effects in elderly patients with hypertension,can significantly improve the vasoactive substances in patients,and increase the rate of blood pressure control up to the standard,and its incidence of adverse drug reactions.
文章编号:3202410027     中图分类号:R544.1    文献标志码:
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章璞,郭杰,龚天  
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